Growth Hormone Secretagogue Research: CJC-1295, Ipamorelin and Tesamorelin

The growth-hormone (GH) axis is a classic subject of endocrine research. Two families of synthetic peptides are used as tools to study it: GHRH analogs and growth hormone secretagogues (GHS). This overview is educational and for laboratory research use only.

GHRH analogs: CJC-1295 and Tesamorelin

Growth-hormone-releasing hormone (GHRH) is the natural signal that tells the pituitary gland to release GH. CJC-1295 is a modified analog of the first 29 amino acids of GHRH. The version listed as CJC-1295 no DAC (also called modified GRF 1-29) lacks the drug-affinity-complex that extends half-life, which makes its activity short, while the DAC version is designed to last longer; both appear in the Individual Products category. Tesamorelin is a longer GHRH analog stabilized by a trans-3-hexenoyl group on its N-terminus, and it has been widely examined in the published literature.

Ghrelin-receptor agonists: Ipamorelin

Ghrelin is a hormone that acts on the growth hormone secretagogue receptor (GHS-R1a). Ipamorelin is a synthetic pentapeptide that binds that receptor and is described in preclinical papers as comparatively selective for GH release. Researchers often contrast it with older secretagogues such as GHRP-6.

Why researchers pair them

The two pathways are distinct, and laboratory models can examine whether signalling through both has different outcomes from either alone. That is the rationale for the CJC no DAC/Ipamorelin vial in our Blends category. As always, a blend needs a separate quantity check for each component.

What the documentation shows

The CJC-1295 no DAC report on the COAs page shows an HPLC purity of 99.46% for a 10 mg vial, together with heavy-metal, endotoxin and sterility results. For Tesamorelin we currently publish the safety panel page (heavy metals, endotoxin, sterility); the purity page is not online yet, and the COAs page says so. Read how to interpret these in How to Read a Peptide Certificate of Analysis.

Cautions

These peptides influence a powerful hormonal system, and none is approved for the research uses described here. They must not be used in or on people or animals. If you have a health question, see a licensed clinician. For the matching update, read CJC-1295 no DAC and Tesamorelin safety panels published.